Maine Becomes latest State to Join the ListMARLBOROUGH Mass

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Its production offices arelocated in Portland, Oregon and Los Angeles, California Mrs. Maine Becomes latest State to Join the ListMARLBOROUGH, Mass.(Business Wire)EXACT Sciences Corporation (NASDAQ: EXAS) today reported that as of January 1,2009, twelve states and the District of Columbia have legislative mandatesrequiring that available colorectal cancer (CRC) screening options offered bycertain categories of insurers in these states must include all tests identifiedin the current American Cancer Society (ACS) screening guidelines, which includestool-based DNA (sDNA) screening. The state of Maine, which enacted a legislative mandate covering colorectalcancer screening effective on January 1, 2009, has become the latest state toexplicitly reference CRC screening guidelines, which include sDNA testing. Thelist now includes Alaska, Georgia, Illinois, Indiana, Kentucky, Maine, Maryland,Missouri, Nevada, New Jersey, North Carolina, Rhode Island and the District ofColumbia. An analysis by the American Cancer Society found that screening ratesimproved forty-percent faster in states with strong reimbursement coverage lawsas compared to states without such laws.

"Clearly, we are pleased with the progress with state legislators taking theinitiative to mandate coverage for CRC screening and thereby providing standardof care for their constituents," commented David A. Johnson MD FACG, Professorof Medicine, Chief of Gastroenterology Eastern VA Medical School, Norfolk,Virginia. Althoughprogress is noted, there remains the challenge to get the residual states toinitiate legislation to provide this coverage for CRC screening. Until we haveall states covered, there is work yet to be done." According to the American Cancer Society, only half of those people 50 years ofage and older, the target group for colorectal cancer screening, have receivedrecommended screening tests.

The American Cancer Society estimates that, in theUnited States alone, there were 148,810 new cases of colorectal cancer in 2008. About Colorectal CancerColorectal cancer is the most deadly cancer among non-smoking men and women inthe United States, and the second most deadly cancer overall. Despite theavailability of colorectal cancer screening and diagnostic tests for more than20 years, the rate of early detection of colorectal cancer remains low, anddeaths remain high. It is estimated that roughly one-third of colorectalcancer-related deaths could be avoided if more people underwent regularscreening. Early diagnosis results in a greater than 90 percent, five-yearsurvival rate.